Central ossifying fibroma cof is a benign osseous neoplasm which consists of highly cellular, fibrous tissue with varying amounts of calcified tissue, which resembles the bone, the cementum or both 1, 2. Benign fibroosseous lesions,fibrous dysplasia,cementifying fibroma, ossifying fibroma,peripheral giant cell granuloma 1. Peripheral ossifying broma occurs mostly in craniofacial bones and categorized into two types central and peripheral. Osteofibrous dysplasia is considered as a separate pathological entity in view of its different presentation and treatment, although histopathologically similar to ossifying fibroma. This paper highlights the diverse clinical and histopathological presentations of peripheral ossifying fibroma through three cases encountered. Introduction benign neoplasm of the periodontal tissues are characterised by progressive growth without remarkable symptoms. Peripheral ossifying fibroma pof is a lesion of the gingival tissues 15 representing up to 2% of all oral lesions that are biopsied 1. Peripheral ossifying fibroma of the posterior maxilla. Pof is defined as a well demarcated and occasionally encapsulated lesion consisting of fibrous tissue containing variable amounts of mineralized material resembling. Females are more commonly affected than males, and anterior maxilla is the most prevalent location of involvement. Histopathologic differential diagnoses thorakkal shamim department of dentistry, government taluk head quarters hospital, nilambur, india peripheral ossifying fibroma is a benign neoplasm that.
Case report peripheral ossifying fibroma after natal tooth. Aarthinisha sree balaji dental college and hospital, bharath university, chennai, india abstract. Peripheral ossifying fibroma is one such reactive lesion, for which the etiology is unclear. They tend to persist or increase in size as the child grows but decrease in size or close once. Cementoossifying fibroma is a benign fibroosseous maxillary tumor belonging to the same category as fibrous dysplasia and cementossifying dysplasia. Ossifying fibroma definition of ossifying fibroma by. The lesion is considered part of an ossifying fibroma, but that. Cementoossifying fibroma radiology reference article. American journal of pharmacology and pharmacotherapeutics peripheral ossifying fibroma mimicking pyogenic granuloma a case report sivakumarashankari, gaurav, jayanthi k and kamala r dept.
Peripheral ossifying fibroma has to be differentiated from traumatic fibroma, peripheral giant cell granuloma, pyogenic granuloma, and peripheral odontogenic fibroma. They tend to persist or increase in size as the child grows but decrease in size or close once growth ends. Excision and repair of the peripheral ossifying fibroma. This lesion generally affects women in the second decade of life. Non ossifying fibroma risks, symptoms and leading causes. We also had a non ossifying fibroma with aneurysmal bone cyst type changes.
Sporadic multiple ofs must be distinguished from hyperparathyroidismjaw tumour syndrome hptjt related of and other fibroosseous lesions. Peripheral cementoossifying fibroma is a relatively rare tumour classified between fibroosseous lesions. Gingiva, fibroma, reactive lesion, peripheral ossifying fibroma 1. Peripheral ossifying fibroma pof is a nonneoplastic enlargement of gingiva that is classified as a reactive hyperplastic inflammatory lesion. The clinical and histological data of 51 cases of peripheral ossifying fibroma were retrieved from the records of department of oral pathology and microbiology, a. Peripheral ossifying fibroma is a fairly common lesion, representing % of all oral biopsies in most series. Nov 10, 2015 the purpose of the present article was to present a clinical case of an 11yearold girl with peripheral ossifying fibroma pof. Peripheral ossifying fibroma pof is a focal, reactive, nonneoplastic tumorlike growth of the soft tissue occurring frequently in the maxillary anterior region, mainly affects females, predominating in the second decade of life. And tomorrow i get to gross in a humeral head osteosarcoma and a liposarcoma of the thigh as well as my 15 lung cancers and 15 femoral heads and probably 5 neck dissections. Peripheral ossifying fibroma a clinical and histological evaluation of 51 cases p. American journal of pharmacology and pharmacotherapeutics. Peripheral ossifying fibroma europe pmc article europe. The peripheral ossifying fibroma pof, one of the most common gingival lesions, has a recurrence rate of nearly 20%.
Orthopaedic institute for children nonossifying fibroma. First description of ossifying fibroma was given by menzel in 1872 while the term was given by montgomery in 1927. Two cases of multiple ossifying fibromas in the jaws. Ossifying fibromas are benign bone lesions that should be differentiated from nonossifying fibromas and fibrous dysplasia. Here, we present a case involving a 1dayold boy with pof, diagnosed after the analysis of a soft tissue mass with a calcified structure that was found after the extraction of a natal tooth, and. Surgical management of ossifying fibroma in maxilla. Children and adolescents are the most common group of age affected. Its origin is believed to be from periodontal membrane, and it shows more predilection toward females.
Peripheral ossifying fibroma is a focal, reactive, nonneoplastic tumorlike growth of the soft tissue that often arises from the interdental papilla 1. Jan 14, 20 the concept of fibroosseous lesions of bone has evolved over the last several decades and now includes two major entities. A case of pof in the maxillary gingiva of a 20 year old male patient is described in this report. The clinicopathologic characteristics of multiple ossifying fibroma of are unclear due to the conditions rarity, making diagnosis challenging. It comprises fibrous tissue containing a variable quantity of mineralized material resembling bone andor cement, whence the term cementoossifying. Pof typically presented as a solitary, slow growing nodular mass that is either pedunculated or sessile.
The central type of ossifying fibroma arises from the endosteum or the periodontal ligament. It is rare in children in relation to primary dentition milk teeth and incidence declines after the age of 30 years. The most common location are the distal femoral and distal tibial methaphyses. S, ravi david austin department of oral medicine and radiology, rajah muthiah dental college and hospital, annamalai university, chidambaram, tamil nadu, india 608002. Cementoossifying fibroma of the mandible sciencedirect.
Peripheral ossifying fibroma a clinical and histological. A rare case report p rajesh raj1, esha nausheen1, nadah najeeb rawther1, jittin james2 1postgraduate student, department of oral medicine and radiology, mar baselios dental college, ko thamangalam, kerala, 2senior lecturer. Case report open access juvenile ossifying fibroma who. It has been reported from birth to old age, but peaks in the teenage years.
The purpose of the present article was to present a clinical case of an 11yearold girl with peripheral ossifying fibroma pof. A nof is a result from failure of the bone to properly close at its outer shell. Peripheral ossifying fibroma pof is characterized by reactive gingival hyperplasia, and it is prevalent in adolescents, but rare in infants. Osteofibrous dysplasia is a rare, benign nonneoplastic condition with no known cause. More chandramani, thakkar krushna, mukesh asrani2011 cemento ossifying fibroma indian journal of dental research222 5. The ossifying fibroma of is a benign neoplasm that affects the jaws. Ossifying fibromas are benign bone lesions that should be differentiated from non ossifying fibromas and fibrous dysplasia. Pofs are frequently associated with irritants like calculus, plaque, dental appliances, ill fitting crowns and rough restorations. In the 2005 who histological classification of odontogenic tumors, this tumor is referred to as ossifying fibroma but in this article, the term cemento ossifying tumor is used to differentiate from peripherally occurring ossifying fibromas. Nonossifying fibroma is a benign intracortical, multilocular and well circumscribed lesion that affects young patients.
Other terms used in reference to pof are peripheral cementifying fibroma, peripheral fibroma with cementogenesis, peripheral fibroma with osteogenesis, peripheral fibroma with calcification, calcified. The growth is measured in terms of months or years and they are often. Peripheral ossifying fibroma is a reactive lesion and originates from the periodontal ligament 2. Peripheral odontogenic fibroma is an uncommon neoplasm that is believed to arise from odontogenic epithelial rests in periodontal ligament or attached gingiva itself.
A 20yrold apparently healthy male patient reported to the department of periodontics. Ossifying fibroma occurs mostly in craniofacial bones and is generally categorized into two types. Juvenile ossifying fibroma who type rathore as1, ahuja p1 and chhina s2 1depmtar ent of oral and maxilofacil al phatolog, yi. It is highly aggressive and has a high tendency to recur. Neoplasm composed of fibrous tissue contains a variable mixture of bony trabeculae, cementumlike spherules, or both neville, 2002 cementoossifying fibroma cementifying fibroma osteogenic neoplasm. Trabecular type of juvenile ossifying fibroma a rare.
Juvenile ossifying fibroma jof is a rare controversial fibroosseous lesion affecting the craniofacial skeleton and occurring commonly in childrens and young adults. To minimize the reappearance of this lesion, it must be completely excised. Usually, of appears as a single, painless and slowgrowing lesion, mostly found in the posterior region of the mandible, specifically in the premolars and molars area 2, 3. It is most commonly seen between the third and fourth decades of. It may be pedunculated or broad based, usually smooth surfaced and varies from pale pink to cherry red in color. Due to its clinical and histopathological similarities, some pofs are believed to develop initially as a pyogenic granuloma that. Menzel first described the lesion ossifying fibroma in 1872 5, but its terminology was given by montgomery in 1927.
However, certain authors have stated that peripheral ossifying fibroma is a variant of central ossifying fibroma and, therefore, a neoplastic process. Ossifying fibromas are benign asymptomatic neoplasms of the maxillae that generally have slow growth and present proliferation of fibrous cell tissue, with a varying quantity of bone products that include bone, cement or a combination of these. It is considered to be the soft tissue counterpart to central ossifying fibroma. Pofs comprises of, one or more mineralized tissues, including bone, cementum like material or dystrophic calcification, within a matrix of cellular fibroblastic tissue 2. Peripheral ossifying fibroma pof is usually a fibroma of the gingival which shows areas of calcification or ossification. Ossifying fibroma is an uncommon benign osteogenic neoplasm, and it is derived from the multipotential mesenchymal cells of the periodontal ligament. It is distinguished from the adult variant of ossifying fibroma on the basis of age, site, cilinical behaviour and. Cemento ossifying fibroma is a benign, non odontogenic tumour of the jaw, a subdivision of. This lesion occurs more often in females in the third and fourth decades of life. Multiple of cases were identified from ossifying fibroma cases. Peripheral ossifying fibroma pof is a reactive lesion of the gingival tissues that predominantly affects women and is usually located in the maxilla anterior to the molars. A nonossifying fibroma nof is one of the most common benign bone tumors found in 30 to 40% of children between 820 years of age. Peripheral ossifying fibroma a case report article pdf available in journal of the indian dental association 5. The varying clinical presentations of peripheral ossifying.
Other synonyms of cemento ossifying fibroma besides ossifying fibroma include 7. Menzel rst described the lesion ossifying broma in, but its terminology was given by montgomery in. This condition should be differentiated from nonossifying fibroma and fibrous dysplasia of bone. It originates from the proliferation of fibrous tissue and histocytes. Cemento ossifying fibroma is a benign fibroosseous maxillary tumor belonging to the same category as fibrous dysplasia and cement ossifying dysplasia. Campanacci described this condition in two leg bones, the tibia and fibula, and coined the term. Histopathologic differential diagnoses thorakkal shamim department of dentistry, government taluk head quarters hospital, nilambur, india peripheral ossifying fibroma is a benign neoplasm that usually develops from gingiva, presenting as an. Lesions histologically similar to peripheral ossifying fibroma have been given various names in existing literature. It was first described as relatively uncommon, solitary, nonneoplastic gingival growth by eversol and robin. Ossifying fibroma is a benign bone neoplasm often considered to be a type of fibroosseous lesion.
Peripheral ossifying fibroma, also known as ossifying fibrous epulis, is a gingival nodule which is composed of a cellular fibroblastic connective tissue stroma which is associated with the formation of randomly dispersed foci of mineralised products, which consists of bone, cementumlike tissue, or a dystrophic calcification. Peripheral ossifying fibroma pof is a relatively common gingival growth that is considered to be reactive in nature and postulated to appear secondary to irritation or trauma. Cemento ossifying fibroma of the jaw dental jounal424 3. The cemento ossifying fibroma is odontogenic in origin, whereas ossifying fibroma is of bony origin. Shetty memorial institute of dental sciences, mangalore. Cementoossifying fibroma is a benign osteogenic tumor with membranous ossification. Riani sieman, peter agus 8th feb 2008 introduction ossifying fibroma. The term ossifying fibroma includes lesions with similar histological compositions and different forms of clinical behavior.
However, peripheral giant cell granuloma can be ruled on the basis of size of the lesion. The histomorphogenic spectrum of peripheral ossifying fibroma. Intraoral ossifying fibromas have been described in the literature since the late 1940s. The peripheral ossifying fibroma pof is a relatively uncommon reactive lesion of the gingiva, associated with mineralization and. It originates from the cells of the periodontal ligament.
Peripheral ossifying fibroma definition of peripheral. Peripheral ossifying fibroma pof is a lesion of the gingival tissues that predominantly affects women and is usually located in the maxilla anterior to the molars. Commonly used synonyms include cementifying fibroma, peripheral. They are noncancerous and do not spread to other areas of the body.
Jun 06, 20 the peripheral ossifying fibroma pof, one of the most common gingival lesions, has a recurrence rate of nearly 20%. The site for its occurrence is mostly on the gingiva, anterior to the molars, interdental papillary region and in maxilla 3. Usually, of appears as a single, painless and slowgrowing lesion, mostly found in the posterior region of the mandible, specifically in the premolars and molars area. The cementoossifying fibroma is odontogenic in origin, whereas ossifying fibroma is of bony origin. It therefore involves exclusively the maxillofacial bones 1, 2. Peripheral ossifying fibroma pof is a reactive soft tissue growth that is usually seen on the interdental papilla. Peripheral ossifying fibroma pof is a reactive gingival overgrowth which is relatively uncommon in nature. Massive ossifying fibroma of mandible pubmed central pmc. Many names have been given to similar lesions, such as epulis,1 peripheral fibroma with calcification,1 peripheral ossifying fibroma,2,3 calcifying fibroblastic granuloma,4 peripheral cementifying fibroma, peripheral fibroma with cementogenesis5. Peripheral cemento ossifying fibroma is a relatively rare tumour classified between fibroosseous lesions. The concept of fibroosseous lesions of bone has evolved over the last several decades and now includes two major entities. Peripheral cemanto ossifying fibroma a case report.
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